Randomized Controlled Trial
The Effects of Blood Flow Restriction (BFR) Training at Different Pressures on Testosterone, Growth Hormone, IGF-1, and Lactate Levels
LayMed Simplified Version
Performing weight training while restricting blood flow to the target muscles significantly boosts muscle-building hormones like Growth Hormone, Testosterone, and IGF-1, as well as Blood Lactate levels, even while lifting relatively light weight (30% 1-RM). While this is true even at low BFRĀ pressures, the effect is greatest at higher pressures.
According to this study, when compared to weight training without BFR, adding high-pressure BFR (70% AOP) to the same training protocol triggers:
- 2.1x more Growth Hormone
- 6.25x more Testosterone
- 5.5x more IGF-1
- 4.8x more Blood Lactate
Blood Flow Restriction Training:
BFR training involves doing exercises (usually with relatively light weight) while partially restricting blood flow to and from the target muscles using an inflatable cuff at pressures that are based on a percentage of the user’s blood pressure.
This method has multiple proven benefits (including increased muscle size, strength, and endurance), and is particularly useful for people who still want to gain the benefits of high-load exercises without putting too much strain on their joints or tissues, since doing low-weight exercises with BFR has been shown to provide the same or greater gains as high-load exercises.
Anabolic Hormones:
How effectively we can build muscle (and burn fat) is largely dependent on a set of hormones within our bodies that regulate muscle-growth processes. As a group theyāre often referred to as āanabolic hormonesā. Three of the most important and potent anabolic hormones are Testosterone (especially for men), Growth Hormone, and IGF-1. Blood lactate levels are also important, since research has shown that high lactate levels increase the production and release of both Testosterone and Growth Hormone in the body.
These anabolic hormones are temporarily elevated in the body by weight training, and that hormonal increase is considered to be one of the primary things that trigger muscle growth in response to the training. Therefore itās in many peopleās interest to figure out ways to enhance their hormonal response to weight training.
Twenty-five healthy young men were randomly separated into three different groups:Ā
Ā Ā Ā -Group 1) Regular weight training (no BFR)
Ā Ā Ā -Group 2) Weight training with light BFR pressure (40% of arterial occlusion pressure, AOP)
Ā Ā Ā -Group 3) Weight training with higher BFR pressure (70% of AOP)
All participants performed 6 sets of sitting leg extensions and sitting leg curls, with 1 minute rests between sets. Each set had 15 reps with a rep tempo of 3 seconds for both the concentric (positive) and eccentric (negative) phases. The weight used was 30% of each participant’s one-repetition maximum (1RM).Ā
For the BFR groups, a 12cm wide cuff was placed and inflated on the upper thigh before beginning the workout, and was removed at the end of each workout.Ā
Blood samples were taken to measure GH, testosterone, IGF-1, and blood lactate levels before exercise, immediately after, 15 minutes after, and 30 minutes after.
The workouts had the following effects on hormone levels for each group (on average):
- Growth Hormone:
- Increased by 1,625% in the high-pressure group
- Increased by 980% in the light-pressure group
- Increased by 775% in the no-BFR group
- Testosterone:
- Increased by 25% in the high-pressure group
- Increased by 15% in the light-pressure group
- Increased by 4% in the no-BFR group
- IGF-1:
- Increased by 11% in the high-pressure group
- Increased by 4% in the light-pressure group
- Increased by 2% in the no-BFR group
- Blood Lactate (BLA):
- Increased by 507% in the high-pressure group
- Increased by 265% in the light-pressure group
- Increased by 106% in the no-BFR group
Figures
Disclaimer: This simplified version is LayMedās own interpretation of the original articleās text, and may or may not accurately reflect the beliefs, views, or findings of the authors. The article was published in September 2021 in theĀ Journal of International Medical Research, and the copyright is owned by the authors.



